Researchers at Harvard Medical School and Brigham and Women's Hospital designed an ingestible capsule that delivers liquid mRNA to the intestines, producing gene expression and reducing inflammation in rats.
  • HubertManne@piefed.socialEnglish
    13·
    5 days ago

    RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.

    Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.

    oh man. as a needlephobe. please. please. please.

    • pressedhams@lemmy.blahaj.zone
      8·
      5 days ago

      I just saw a similar article about using this delivery method for insulin. I’m just some plebeian but it’s all very interesting!

      • HubertManne@piefed.socialEnglish
        3·
        5 days ago

        no prob. If I read the article I usually try to paste what I feel is the most relevant bit and once in awhile I will do the whole thing or if its too long I will add a comment encouraging people to read the article if its good enough.